As its name suggests, eastern equine encephalitis (EEE) is a disease affecting horses as well as humans. EEEV is infrequently detected in Indian River County, only one human EEE case having been recorded. EEEV activity is much more common in northern and central Florida. The life cycle of this virus is poorly understood in Florida and probably involves different mosquito species than in more northern states. The virus is associated with birds and mosquitoes frequenting freshwater swamps.